How long does the action of Physostigmine typically last?

How long does the action of Physostigmine typically last?

• A. 5-15 minutes
• B. 30-120 minutes
• C. 1-3 hours
• D. 24 hours

Answer: (B)

The duration of action for Physostigmine typically falls within the range of 30 to 120 minutes. Physostigmine is a reversible inhibitor of the enzyme acetylcholinesterase, which leads to an accumulation of acetylcholine at synaptic clefts. This action is particularly useful in treating anticholinergic toxicity and in conditions like glaucoma. The relatively short duration of action is crucial in clinical settings, as it allows for more precise control of acetylcholine levels and minimizes the risk of prolonged cholinergic effects, which can lead to side effects. This timeframe of 30 to 120 minutes reflects the pharmacokinetics of Physostigmine, balancing the need for effective treatment while allowing for the medication to be cleared relatively quickly from the system. This characteristic supports strategic dosing in clinical scenarios where continuous monitoring is necessary.

The duration of action for Physostigmine typically falls within the range of 30 to 120 minutes. Physostigmine is a reversible inhibitor of the enzyme acetylcholinesterase, which leads to an accumulation of acetylcholine at synaptic clefts. This action is particularly useful in treating anticholinergic toxicity and in conditions like glaucoma. The relatively short duration of action is crucial in clinical settings, as it allows for more precise control of acetylcholine levels and minimizes the risk of prolonged cholinergic effects, which can lead to side effects.

This timeframe of 30 to 120 minutes reflects the pharmacokinetics of Physostigmine, balancing the need for effective treatment while allowing for the medication to be cleared relatively quickly from the system. This characteristic supports strategic dosing in clinical scenarios where continuous monitoring is necessary.