What process occurs after ACh binds to its receptor?

What process occurs after ACh binds to its receptor?

• A. Recycling
• B. Inhibition
• C. Degradation
• D. Uptake into storage

Answer: (C)

After acetylcholine (ACh) binds to its receptor, the process that occurs is degradation. This is primarily carried out by the enzyme acetylcholinesterase, which breaks down ACh into acetate and choline. This is a crucial step in cholinergic signaling, as it ensures that the neurotransmitter does not continue to occupy the receptor for an extended period, which would lead to continuous stimulation and possible desensitization of the receptor. Degradation is essential for terminating the signal; if ACh were to remain bound to its receptor, it could lead to prolonged activation of postsynaptic cells, which might result in adverse effects, such as muscle spasms or erratic signaling within the nervous system. The breakdown products, particularly choline, can also be recycled back into the presynaptic neuron to synthesize new molecules of ACh, maintaining the balance in cholinergic transmission. This careful regulation exemplifies the body's sophisticated methods of controlling neurotransmission and maintaining homeostasis.

After acetylcholine (ACh) binds to its receptor, the process that occurs is degradation. This is primarily carried out by the enzyme acetylcholinesterase, which breaks down ACh into acetate and choline. This is a crucial step in cholinergic signaling, as it ensures that the neurotransmitter does not continue to occupy the receptor for an extended period, which would lead to continuous stimulation and possible desensitization of the receptor.

Degradation is essential for terminating the signal; if ACh were to remain bound to its receptor, it could lead to prolonged activation of postsynaptic cells, which might result in adverse effects, such as muscle spasms or erratic signaling within the nervous system. The breakdown products, particularly choline, can also be recycled back into the presynaptic neuron to synthesize new molecules of ACh, maintaining the balance in cholinergic transmission. This careful regulation exemplifies the body's sophisticated methods of controlling neurotransmission and maintaining homeostasis.