Which reversible AChE inhibitor is known for its oral administration options?

Which reversible AChE inhibitor is known for its oral administration options?

• A. Galantamine
• B. Rivastigmine
• C. Donepezil
• D. Physostigmine

Answer: (C)

Donepezil is the reversible acetylcholinesterase (AChE) inhibitor primarily known for its suitability for oral administration. It is commonly prescribed for the treatment of Alzheimer's disease and functions by increasing the concentration of acetylcholine in the synaptic cleft, enhancing cholinergic transmission. This action supports cognitive function in individuals with Alzheimer's. Galantamine and rivastigmine are also reversible AChE inhibitors used in the management of Alzheimer's disease, but rivastigmine is primarily available in patch form and is less commonly administered orally compared to donepezil. Physostigmine, while it is an AChE inhibitor, is not typically administered orally; it is primarily used in acute settings and administered parenterally due to its rapid action and central nervous system effects. Thus, donepezil stands out for its efficacy and ease of use via oral administration.

Donepezil is the reversible acetylcholinesterase (AChE) inhibitor primarily known for its suitability for oral administration. It is commonly prescribed for the treatment of Alzheimer's disease and functions by increasing the concentration of acetylcholine in the synaptic cleft, enhancing cholinergic transmission. This action supports cognitive function in individuals with Alzheimer's.

Galantamine and rivastigmine are also reversible AChE inhibitors used in the management of Alzheimer's disease, but rivastigmine is primarily available in patch form and is less commonly administered orally compared to donepezil. Physostigmine, while it is an AChE inhibitor, is not typically administered orally; it is primarily used in acute settings and administered parenterally due to its rapid action and central nervous system effects. Thus, donepezil stands out for its efficacy and ease of use via oral administration.